#Breakthrough: HIV long term remission achieved through stem
In a significant development, a person with HIV infection has been reported to be experiencing remission for the last 18 months after antiretroviral therapy (ART) was stopped following stem-cell transplantation in London. Remission is when HIV RNA (ribonucleic acid) is undetectable in blood. ART is used for treating HIV.

The person with HIV was diagnosed with advanced Hodgkin’s lymphoma, a form of cancer, in 2012. To treat the cancer, stem cells which give rise to blood cells were transplanted from a donor who had two mutant copies of a co-receptor for HIV infection. This exercise was carried out in London. The co-receptor (CCR5) is used by the HIV virus to gain entry into host cells in humans. But a mutant does not allow the virus to enter the host cells and hence makes the person resistant to HIV infection.

This is the second instance when HIV remission has been achieved through transplantation of stem cells carrying two copies of the mutant co-receptor. The first case was in 2009; no viral rebound was then seen even 20 months after transplantation and discontinuation of ART therapy.

It may have been years since the famous 'Berlin patient' made history by becoming the first person to sustain HIV–1 remission without receiving anti-retroviral (ARV) drugs, but the newly announced case of an anonymous male British patient demonstrates the first result was not unique.

In the present study, the research team led by Prof. Ravindra K. Gupta from University College London first ascertained that following transplantation, the recipient had two copies of the mutant. ART was stopped 16 months after transplantation. The HIV RNA has remained undetectable in blood for 18 months after ART was stopped. The results were published today (March 5) in Nature.

Read more: https://www.thehindu.com/sci-tech/science/hiv-remission-achieved-through-stem-cell-transplantation/article26432696.ece
Dr. P●●●●●e G●●g and 46 others like this35 shares
Dr. A●●t S●●●●a
Dr. A●●t S●●●●a Internal Medicine
Mar 6, 2019Like
S●●●●●p K●●●r W●●●●●e
S●●●●●p K●●●r W●●●●●e General Medicine
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Dr. H●●●●h D●●●i
Dr. H●●●●h D●●●i Obstetrics and Gynaecology
Great news for PLHA patients & also for stem cell research.
Mar 6, 2019Like