C1q nephropathy in a patient of neurofibromatosis type 1: A
A 51-year-old married male presented with complaints of swelling over lower limbs, face, and abdomen along with frothy urine for last 1 month. There was no history of preceding fever, sore throat, joint pain, rash, or hematuria. There was no past history of similar complaints, hypertension, diabetes, chronic analgesic or other drug abuse, blood transfusion, or any high-risk sexual behavior.

On admission, he was conscious, cooperative, and oriented to time, place, and person. He was afebrile; had a pulse rate of 82 beats/min, regular, normal volume; and had blood pressure of 126/82 mmHg with a respiratory rate of 18 breaths/min. There was the presence of facial puffiness and pitting pedal edema. On per abdomen examination, there was generalized abdominal distention with fullness of flanks, and on percussion, there was shifting dullness confirming the presence of ascites. His respiratory and cardiovascular examination was unremarkable. He had multiple purplish, well-circumscribed, and pedunculated skin lesions over face, chest, abdomen, and back. Also, on the trunk was presence of many café-au-lait spots of more than 1.5 cm in diameter. An Ophthalmological examination revealed two Lisch nodules in iris in the left eye and three in the right eye.

There was a history of similar skin lesions in patient's father and paternal grandfather although no history of renal disease was present. The diagnosis of NF-1 was made as per the National Institute of Health Criteria.

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