CABANA: AF ablation potentially superior to drug therapy amo
Patients from underrepresented racial and ethnic groups benefited significantly from catheter ablation compared with drug therapy for the treatment of atrial fibrillation, according to new data from the CABANA trial.

Rhythm control strategies for atrial fibrillation (AF), including catheter ablation, are substantially underused in racial/ethnic minorities in North America.

This study sought to describe outcomes in the CABANA trial as a function of race/ethnicity.

CABANA randomized 2,204 symptomatic participants with AF to ablation or drug therapy including rate and/or rhythm control drugs. Only participants in North America were included in the present analysis, and participants were subgrouped as racial/ethnic minority or nonminority with the use of National Institutes of Health definitions. The primary endpoint was a composite of death, disabling stroke, serious bleeding, or cardiac arrest.

Results:
-- Of 1,280 participants enrolled in CABANA in North America, 127 (9.9%) were racial and ethnic minorities.

-- Compared with nonminorities, racial and ethnic minorities were younger with median age 65.6 versus 68.5 years, respectively, and had more symptomatic heart failure (37.0% vs 22.0%), hypertension (92.1% vs 76.8%, respectively), and ejection fraction <40% (20.8% vs 7.1%).

-- Racial/ethnic minorities treated with ablation had a 68% relative reduction in the primary endpoint.

-- Primary event rates in racial/ethnic minority and nonminority participants were similar in the ablation arm (4-year Kaplan-Meier event rates 12.3% vs 9.9%); however, racial and ethnic minorities randomized to drug therapy had a much higher event rate than nonminority participants (27.4% vs. 9.4%).

Conclusively, among racial or ethnic minorities enrolled in the North American CABANA cohort, catheter ablation significantly improved major clinical outcomes compared with drug therapy. These benefits, which were not seen in nonminority participants, appear to be due to worse outcomes with drug therapy.

Source: https://www.jacc.org/doi/abs/10.1016/j.jacc.2021.04.092
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