COVID-19: Could Hydroxychloroquine Really Be the Answer?
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
Generic malaria drug hydroxychloroquine (Plaquenil, Sanofi-Aventis, among others), which is also used for the treatment of rheumatic disease, could be an essential treatment for COVID-19.

This hypothesis, put forward by Professor Didier Raoult of the IHU Méditerranée Infection in Marseille, was ruled out due to the risk of interactions with other medications for common comorbidities in infected patients, and because of possible adverse effects in patients undergoing resuscitation.

#The Marseille Study

-- The European Union Clinical Trials Register presented that the Marseille study was accepted on 5th March by the National Medicines Safety Agency (ANSM). It could include up to 25 COVID-19 positive patients, comprising five aged 12–17 years, 10 aged 18–64 years, and 10 more aged 65 years or over.

-- While the data have not yet been published, and should, therefore, be interpreted with caution, this non-randomized, unblinded study showed a strong reduction in viral load with hydroxychloroquine.

-- After 6 days, the percentage of patients testing positive for COVID-19 who received hydroxychloroquine fell to 25% versus 90% for those who did not receive the treatment.

-- In addition, comparing untreated patients, some receiving hydroxychloroquine and others given hydroxychloroquine plus the antibiotic azithromycin, the results showed there was "a spectacular reduction in the number of positive cases" with the combination therapy, said Raoult.

-- At 6 days, among patients given combination therapy, the percentage of cases still carrying SRAS-CoV-2 was no more than 5%.

Azithromycin was added because it is known to be effective against complications by bacterial lung disease but also because it has been shown to be effective in the laboratory against a large number of viruses, the infectious disease specialist explained.

#Hydroxychloroquine Tested in Other Hospitals

Chloroquine is currently being examined in a number of clinical studies in China and elsewhere, and some in France have also decided to suggest it following Prof Raoult’s findings.

In the UK, Robin May, Professor of Infectious Disease at the University of Birmingham, explained that, as chloroquine is a "weak base" and so helps to neutralize acids, it makes the environment "less suitable" for the malaria parasite to live in when it diffuses into red blood cells.

While the mode of action against COVID-19 is not established, Prof May said, he pointed out that many viruses enter host cells via endocytosis, as a result of which they are initially taken up into an intracellular 'compartment that is "typically fairly acidic”. "Chloroquine would alter the acidity of this compartment, which can interfere with the ability of viruses to escape into the host cell and start replicating.”

He continued: "Another possibility is that chloroquine may alter the ability of the virus to bind to the outside of a host cell in the first place,” adding that the drug "has subtle effects on a wide variety of immune cells…and it may be that one of these effects helps stimulate the body’s ability to fight off COVID-19. Crucially, the drug is also "cheap and relatively easy to manufacture" and so could easily be put into clinical trials and, eventually, treatment.”

Note: Detailed study published on “Clinical Infectious Disease” Journal is attached as pdf.

A●●●●●a T●●●●i and 3 others like this7 shares
G R K●●●●a V●●●●●●i
G R K●●●●a V●●●●●●i General Medicine
When will Chloroquine be confirmed as drug of choice for COViD 19?
Mar 23, 2020Like1
N●●a R●●●●●r
N●●a R●●●●●r Obstetrics and Gynaecology
Hey, Thank you for sharing your query. Recently, ICMR has recommended the use of hydroxy-chloroquine for prophylaxis of COVID-19 infection for high-risk population which includes: -- Asysmptomtic healthcare workers involved in the case of suspected or confirmed case of COVID-19 -- Asymptomatic household contacts of laboratory-confirmed cases. For more details you may check out our post: Read more
Mar 24, 2020Like1
V●●●k 7
v●●●k 7 General Medicine
Isn' t this combination is dangerous? Bcs hydroxychloroquine +Azithromycin combo causes sudden arrythmias n QTprolongation
Mar 28, 2020Like