#COVID-19: Person’s immune system defeated the Coronavirus
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Melbourne researchers have mapped immune responses from one of Australia’s first novel coronavirus (COVID-19) patients, showing the body’s ability to fight the virus and recover from the infection.

The scientists were able to conduct a case study using information about one of the first hospital patients with a SARS-CoV-2 infection in Australia. This was a 47-year-old female who had traveled to Melbourne from Wuhan, China. The female was experiencing mild-to-moderate symptoms of the infection when they sought care, but they were healthy in all other respects.

That is why scientists later became interested in finding out how an otherwise healthy adult’s immune system is able to react to an infection with the new virus. “We showed that even though COVID-19 is caused by a new virus, in an otherwise healthy person, a robust immune response across different cell types was associated with clinical recovery, similar to what we see in influenza. This is an incredible step forward in understanding what drives the recovery of COVID-19. People can use our methods to understand the immune responses in larger COVID-19 cohorts, and also understand what’s lacking in those who have fatal outcomes,” says study co-author.

#Influx of key immune cells

The female sought specialized care 4 days after the onset of viral infection symptoms. These symptoms included lethargy, a sore throat, a dry cough, pleuritic chest pain, some shortness of breath, and a fever. They were able to leave the hospital and enter self-isolation 11 days after symptom onset, and they were symptom-free by day 13.

In their study, the researchers analyzed blood samples that healthcare professionals had collected from the patient on four different occasions: on days 7, 8, 9, and 20 following symptom onset. “We looked at the whole breadth of the immune response in this patient using the knowledge we have built over many years of looking at immune responses in patients hospitalized with influenza,” explains study co-author Dr. Oanh Nguyen.

The researchers found that during days 7–9 following symptom onset, there was an increase in immunoglobulin G — which is the most common type of antibody — rushing to fight the virus. There was also an increase in immunoglobulin M. This increase in immunoglobulins persisted up to day 20 after symptom onset, according to the analyses. At days 7–9 following symptom onset, a large number of specialized helper T cells, killer T cells, and B cells — all of which are crucial immune cells — were also active in the patient’s blood samples.

This suggested that the patient’s body had been using many different “weapons” effectively against the new virus. “Three days after the patient was admitted, we saw large populations of several immune cells, which are often a tell-tale sign of recovery during seasonal influenza infection, so we predicted that the patient would recover in 3 days, which is what happened,” notes Dr. Nguyen.

Note: Detailed study is attached as pdf.
Source: https://www.nature.com/articles/s41591-020-0819-2
T●●●i C●●●●●n and 31 others like this33 shares
S●●●●●h S●●●h
S●●●●●h S●●●h General Medicine
Newer generation immunity boosters are the demand of time now. Research is needed in this field. If anyone wants to join then ping me!
Mar 28, 2020Like11
S●●●i T●●●●●●i
S●●●i T●●●●●●i General Medicine
Researched a lot about covid-19, but really keen on working on it further..
Mar 28, 2020Like1