COVID reinfection more severe for four Mumbai health workers
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Reinfection of Covid-19 has been confirmed using whole-genome sequencing in four healthcare workers from Mumbai.

All four have a more severe Covid-19 infection as compared to their earlier episode, according to a preprint published in The Lancet.

The four reinfected patients include three doctors from the BMC-run Nair Hospital and another healthcare worker from Hinduja Hospital.

The research found 39 mutations within eight genomes (four samples each of the first infection and four samples from the second infection).

For all four HCWs, the second episode had more symptoms, with constitutional manifestations and illness that lasted longer than the first episode.

While the first Covid infection was asymptomatic to mild in these healthcare workers, all needed hospitalization the second time around. None of them, however, developed breathlessness or infection in their lower respiratory tract.

"This can perhaps be explained by their young age,” Dr Jayanthi Shastri from Nair Hospital said.

One of the main aims of the paper is to underline the risk, a repeated one at that, faced by healthcare workers. “Older HCWs may experience more severe respiratory involvement,” she added.

Source: https://health.economictimes.indiatimes.com/news/diagnostics/those-reinfected-have-more-severe-infection/78266577
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