Can a Genetic Test Help Detect Early Kidney Disease?
Researchers developed a polygenic risk score for chronic kidney disease (CKD) that performed well across ancestrally diverse populations. The risk score combines risk from APOL1 gene variants — which confer a high risk of CKD among Black persons — as well as small risks from thousands of other gene variants. They combined APOL1 risk genotypes with GWAS for kidney function and designed, optimized, and validated a genome-wide polygenic score for CKD. They then tested the score in 15 independent cohorts, including three cohorts of European ancestry (with a total of 97,050 people), six cohorts of African ancestry (14,544 people), and four cohorts of Asian ancestry (8625 people), and two admixed Latinx cohorts (3625 people).