Can you get COVID-19 twice?
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The authors of this case study evaluated the possibility of true COVID-19 reinfection.

Whole-genome sequencing was performed directly on respiratory specimens collected during 2 episodes of COVID-19 in a 33-year-old male patient who was apparently immunocompetent. Comparative genome analysis was conducted to differentiate reinfection from persistent viral shedding. Laboratory results, including RT-PCR values and serum SARS-CoV-2 IgG, were analyzed. The patient was discharged from the first episode of COVID-19 on April 14, 2020, after 2 negative SARS-COV-2 RT-PCR assays on nasopharyngeal and throat swabs taken 24 hours apart.

The second episode of asymptomatic infection occurred on August 15, 2020, approximately 4.5 months after the first symptomatic episode. Viral genomes from first and second episodes belonged to different clades/lineages with 24 nucleotide differences. During the second episode, there was serological evidence of elevated C-reactive protein, relatively high viral load with gradual decline and SARS-CoV-2 IgG seroconversion.

The authors performed a blast search for the first and second genome. The first viral genome is most closely related to strains from the United States or England collected in March and April 2020. The second viral genome is most closely related to strains from Switzerland and England collected in July and August 2020.

Epidemiological, clinical, serological, and genomic analyses confirmed that the patient had reinfection instead of persistent viral shedding from the first infection. The results suggest SARS-CoV-2 may continue to circulate among the human populations despite herd immunity due to natural infection or vaccination and true reinfection can occur. It is crucial for even those who have been infected with COVID-19 to take the same prophylactic precautions as those who have not been infected with COVID-19.

Source:https://www.aao.org/editors-choice/can-you-get-covid-19-twice
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