Cannabis Abuse linked with Perioperative Complications Follo
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The primary aim of this study was to analyze the association between cannabis abuse and serious adverse events following elective spine surgery.

Cannabis is the most popular illicit drug in the United States, and its use has been increasing in light of state efforts to decriminalize and legalize its use for both medical and recreational purposes.

The 2012–2015 Nationwide Inpatient Sample was queried for all patients undergoing common elective spine surgery procedures. These patients were then grouped by the presence of concurrent diagnosis of cannabis use disorder and compared with respect to various peri- and postoperative complications, all-cause mortality, discharge disposition, length of stay, and hospitalization costs. Propensity score matching was utilized to control for potential baseline confounders.

--A total of 423,978 patients met inclusion/exclusion criteria, 2,393 of whom had cannabis use disorder.

--After controlling for baseline characteristics and comorbid tobacco use, these patients had similar inpatient mortality, but higher rates of perioperative thromboembolism (OR 2.2), respiratory complications (OR 2.0), neurologic complications such as stroke and anoxic brain injury (OR 2.9), septicemia/sepsis (OR 1.5), and non-routine discharge, as well as increased lengths of stay (7.1 vs. 5.2 days) and hospitalization charges.

In conclusion, cannabis misuse appears to be linked to an increased risk of perioperative morbidity in patients undergoing spine surgery. Physicians should take a detailed preoperative drug use history to ensure that affected patients are fully informed of the risks involved.