Cardiac Biomarkers associated with hospital length of stay a
Prolonged hospital length of stay after congenital heart surgery is a significant cost burden and is associated with postoperative morbidity. The study shows that ST2 in particular could be used to guide an earlier assessment of patient risk for complications that may lead to adverse outcomes.

The goal was to evaluate the association between pre-and postoperative biomarker levels and in-hospital length of stay for children after congenital heart surgery.

Investigators enrolled patients <18 years of age who underwent at least 1 congenital heart operation. Blood samples were collected before the index operation and at the end of the bypass. ST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) measurements were evaluated as log-transformed, median, and tercile cut-points. They evaluated the association between pre-and postoperative NT-proBNP and ST2 measurements with the in-hospital postoperative length of stay.

- In the cohort, 45% of our patients had an in-hospital postoperative length of stay longer than the median.

- Before adjustment preoperative NT-proBNP above the population median and the highest tercile exhibited a significantly longer in-hospital length of stay.

- After adjustment for covariates in the risk model, pre-and postoperative ST2 and NT-proBNP demonstrated a significantly longer length of stay.

In particular, perioperative ST2 and NT-proBNP had a significant association with increased postoperative in-hospital length of stay before and after adjustment.

The Annals of Thoracic Surgery