Cardiac Manifestation Among Children with Hemolytic Uremic S
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The study's main aim was to see if there was a correlation between cardiac symptoms and in-hospital mortality in children with Hemolytic Uremic Syndrome (HUS).

Using the Pediatric Health Information System database, this retrospective, multi-center, cohort study identified the first HUS-related inpatient visit among children less than 18 years. Frequency of selected cardiac manifestations and mortality rates were calculated. Multivariate analysis identified the association of specific cardiac manifestations and the risk of in-hospital mortality.

Results:
--Among 3,915 patients in the analysis, 238 had cardiac manifestations.

--A majority of patients (82.8%) had 1 cardiac condition, (17.2%) had 2, or or more cardiac conditions.

--The most common cardiac conditions was pericardial disease (n=102), followed by congestive heart failure (n=46), and cardiomyopathy/ myocarditis (n=34).

--The percent mortality for patients with 0, 1, 2 or more cardiac conditions was 2.1%, 17.3%, and 19.5%, respectively. Patients with any cardiac condition had an increased odds of mortality (OR 9.74).

--In additional models, the presence of 2 or more cardiac conditions (OR-9.90), cardiac arrest (OR- 38.25), or ECMO deployment (OR- 11.61) were associated with increased risk of in-hospital mortality.

In conclusion, this study found variations in in-hospital mortality depending on the form of cardiac manifestations, with patients who had multiple cardiac involvement, cardiac arrest, or ECMO deployment having a higher risk.

Source: https://www.jpeds.com/article/S0022-3476(21)00316-4/fulltext?rss=yes
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