Cardio-cerebrovascular disease history complicates hematopoi
Patients with previous cardio-cerebrovascular disease (pre-CCVD) may often be poor candidates for hematopoietic cell transplantation (HCT).

A retrospective study was conducted between patients with and without pre-CCVD who consecutively received allogeneic or autologous HCT with a matching of age and disease status. The cardiovascular complications and HCT outcomes of the two groups were evaluated and compared. The primary endpoints were post-transplant cardio-cerebrovascular disease (post-CCVD) and non-relapse mortality (NRM).

The outcomes of 23 HCT recipients with pre-CCVD were compared with those of 107 patients in the control group.

- No significant differences were noted in terms of engraftment, overall survival (OS), or relapse between the pre-CCVD group and the control group.

- The cumulative incidences of 2-year NRM were similar between patients with pre-CCVD and the controls.

- However, pre-CCVD was associated with an increased incidence of post-CCVD, which was an independent risk factor for increased NRM and inferior OS.

These findings suggest that the existence of pre-CCVD before transplantation might not result in increased mortality directly but superpose the toxicity of the transplantation procedure, leading to a risk of post-CCVD. Post-CCVD was a powerful predictor for high NRM and inferior OS.

Chinese Medical Journal