Cardio-metabolic risk factors during childhood in relation t
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Cardio-metabolic risk factors might have an adverse effect on respiratory outcomes, but associations in children are different. Researchers aimed to study the longitudinal associations of cardio-metabolic risk factors with lung function and asthma at school-age & examined whether any association was explained by child’s body mass index (BMI).

In a population-based cohort study among 4,988 children cardio-metabolic risk factors were measured at 6 and 10 years and included blood pressure, cholesterol, triglycerides, insulin and C-reactive protein (CRP) concentrations. At age 10 years, lung function was measured by spirometry and current physician diagnosed asthma was assessed by questionnaire.

Results:
--A higher diastolic blood pressure at the age of 6 years was associated with a higher forced vital capacity (FVC) at the age of 10 years.

--Also, child’s CRP concentrations above the 75th percentile at both age 6 and 10 years were related to a lower FVC as compared to CRP concentrations below the 75th percentile at both ages (Z-score difference (95% CI) -0.21 (-0.36, -0.06)).

--No consistent associations of other cardio-metabolic risk factors with respiratory outcomes were observed.

Finally, blood pressure and CRP were linked to lung function but not asthma.

Source: https://onlinelibrary.wiley.com/doi/10.1111/pai.13509?af=R
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