Cardiovascular disease in diffuse idiopathic skeletal hypero
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This study compares the probability for developing Cardiovascular disease in patients with DISH (diffuse idiopathic skeletal hyperostosis). They have a significantly higher risk to develop myocardial infarction.

The medical records of patients with DISH and controls, (without known CV disease), were reviewed. Demographic, constitutional, and laboratory data were collected. Comparison of CV events was performed according to the outcome definitions set by the Framingham score 2: coronary event demonstrated by a coronary imaging modality, acute myocardial infarction (MI), coronary death, congestive heart failure with a reduced ejection fraction, and angina pectoris.

Data were available for 45 patients with DISH and 47 controls without DISH from the original cohort (91.8% and 97.9% respectively). By the Framingham score, 28.6% of the DISH patients were expected to be affected with CVD at 10 years of follow-up. It was observed that nearly 39% of them developed CVD during that period. The incidence of MI over the 10-year period was significantly higher in the DISH group. It had higher morbidity with a higher composite outcome of 38.8% vs 25.5% in the control cohort, and the number of non-elective hospital admissions per patient, despite neither reaching statistical significance.

The study showed that the Framingham score underestimates the real risk for developing CVD in patients with DISH, specifically the risk for MI. Researchers propose more scrutiny is warranted in evaluating CV risk in these patients, more demanding treatment target goals should be established, and earlier and more aggressive medical interventions should be undertaken, particularly primary prevention.

Source: https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-020-02278-w
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