Case Study in Cardiac Amyloidosis: Daunting But Ever More Tr
In October 2013, a 65-year-old male physician from Dallas diagnosed with hypertrophic cardiomyopathy saw Cleveland Clinic heart failure specialist Mazen Hanna, MD, for a second opinion. The former marathoner had been treated for heart failure for about a year but was rapidly declining.

Finding the patient’s test results inconsistent with the diagnosis (Figure 1), Dr. Hanna ordered more-sensitive tests, which revealed cardiac amyloidosis (Figures 2 and 3) — specifically, AL amyloidosis — that was soon confirmed by biopsy. Chemotherapy was promptly started. The patient returned to Texas, and with a Cleveland Clinic hematologist coordinating his chemotherapy, he achieved very good partial remission....