Celecoxib‐induced bullous fixed drug eruption: An unusual pr
Fixed drug eruption (FDE) is a drug reaction characterized by one or multiple erythematous lesions that recurs in a fixed site after taking the causative drug.

This is a case of celecoxib‐induced BFDE confirmed by an oral provocation test. A 34‐year‐old woman, with no relevant history, was prescribed celecoxib (Inibrex, capsules of 200 mg, Dar‐Essaydali) twice daily for the treatment of painful menstruation. One day later, she manifested an itching and burning sensation in the front face of the neck with a blistering eruption. Thus, she was referred to the Emergency Department.

The physical examination revealed a bullous well‐circumscribed oval plaque measuring 8 cm of diameter located in the front face of the neck extending to the chin without mucosal involvement. Nikolsky's sign was negative. The patient had no fever, and systemic examination did not reveal any abnormality. Thus, celecoxib was discontinued, and the patient was prescribed topical steroids and antihistamines. Two days later, the cutaneous lesion resolved leaving a residual hyperpigmented patch.

Source: British journal of clinical pharmacology

Read more: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.14072