Cement Loaded With High-Dose Gentamicin and Clindamycin Redu
The use of antibiotic-loaded acrylic cement for treating periprosthetic joint infections remains controversial. Researchers hypothesized that the raw rate of surgical site infection (SSI) is lower after using cement loaded with high-dose gentamicin and clindamycin than after using cement loaded with standard-dose gentamicin for implant fixation during 1-stage hip and knee revision arthroplasty for infection.

171 continuous patients operated during a 2-year period were included in the study. All patients were followed for 24 months. The primary endpoint was the raw rate of SSI after 2 years of follow-up time.

--The raw rate of SSI after 2 years of follow-up time was significantly lower in the study group than in the control group with an odds ratio of 0.42.
--These SSIs were new infections rather than a recurrence/persistence of the initial infection.

In conclusion, in relation to the cement employed in the study group the SSI risk in relation to the control group dramatically lowered. Routine use of this dual high-dose antibiotic cement may be regarded as arthroplasty for infection during the 1-phase knee or hip revision.

Source: https://www.sciencedirect.com/science/article/abs/pii/S0883540321006665?dgcid=rss_sd_all