Central obesity, smoking habit and hypertension are associat
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This study aimed to explore variables associated with the serological response following COVID-19 mRNA vaccine.

Eighty-six healthcare workers adhering to the vaccination campaign against COVID-19 were enrolled. All subjects underwent two COVID-19 mRNA vaccine inoculations (Pfizer/BioNTech) separated by three weeks. Blood samples were collected before the first and 1-4 weeks after the second inoculation. Clinical history, demographics, and vaccine side effects were recorded. Baseline anthropometric parameters were measured, and body composition was performed through dual-energy-X-ray absorptiometry.

Results:
-- Higher waist circumference was associated with lower antibody (Ab) titers; smokers had lower levels compared to non-smokers, as well as hypertensive vs normotensive and dyslipidemic compared to those with normal serum lipids.

-- Multivariate analysis showed that higher waist circumference, smoking, hypertension and longer time elapsed since second vaccine inoculation were associated with lower Ab titers, independent of BMI, age and gender.

Conclusively, central obesity, hypertension and smoking are associated with lower Ab titers following COVID-19 vaccination. Although it is currently impossible to determine whether lower SARS CoV-2 Abs lead to higher likelihood of developing COVID-19, it is well-established that neutralizing antibodies correlate with protection against several viruses including SARS-CoV-2. These findings, therefore, call for a vigilant approach, as subjects with central obesity, hypertension and smoking could benefit from earlier vaccine boosters or different vaccine schedules.

Source: https://onlinelibrary.wiley.com/doi/10.1002/dmrr.3465?af=R
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