Cerebellar large B-cell lymphoma: a case report
Primary central nervous system lymphoma PCSNL is a rare, malignant non-Hodgkin lymphoma that can arise in the brain, spinal cord, eye, leptomeninges, or cranial nerves.

Cerebellar involvement is present in only 9% of cases. Published in the Journal of Medical Case Reports, the authors present an unusual case of primary central nervous system lymphoma presenting as multiple lesions in the cerebellum in an immunocompetent host.

A 71-year-old man presented with acute onset of dizziness, nausea, vomiting, and gait imbalance. Contrast-enhanced computed tomography revealed three intensely enhancing masses in the right cerebellar hemisphere. Whole-body positron emission tomography and computed tomography failed to demonstrate a primary tumor of origin outside the central nervous system.

The patient underwent right suboccipital craniotomy with partial resection of the visible tumor from the right cerebellum. Histopathology revealed diffuse large B-cell lymphoma, non-germinal center type.

Key takeaways:-
- This patient, who had multiple lesions in the cerebellum, highlights two unusual presentations of this rare disease that made the initial diagnosis particularly challenging.

-The clinical picture of PCSNL can also mimic posterior circulation stroke presentation, as did this patient. Therefore, this condition must be excluded, keeping in mind that it represents nearly 20% of all ischemic strokes.

- Because imaging in this disease is nondiagnostic, biopsy is crucial to differentiating PCNSL from malignant and benign lesions that present in a similar manner and appear similar on imaging.

- The highly aggressive nature of PCNSL necessitates timely diagnosis and intervention. Therefore, physicians must include this disease in their differential diagnosis of mass lesions found in the central nervous system.

Read in detail here: https://pxmd.co/YzHEj
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Jan 14, 2019Like