Chances of pregnancy no higher with frozen over fresh embryo
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Freezing embryos for later transfer as part of assisted reproductive treatment does not result in a higher chance of pregnancy compared with fresh embryo transfer, finds a study. The researchers say the findings warrant caution in applying an indiscriminate "freeze-all" strategy for all women undergoing assisted reproductive technology treatment, and that fresh embryo transfer should be used as the gold standard. Elective freezing of embryos (a "freeze-all" strategy) is becoming more common as pregnancy rates after frozen transfers approach those of fresh transfers.

A freeze-all strategy can also minimize the risk of ovarian hyperstimulation syndrome (a painful response to hormones used to stimulate egg development), but studies comparing the two strategies are lacking. To help fill this evidence gap, a team of researchers set out to test whether a freeze-all strategy resulted in a higher pregnancy rate than a fresh transfer strategy. Their findings are based on 460 women aged 18-39 years with regular menstrual cycles starting their first, second, or third treatment cycle of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) at fertility clinics. The freeze-all group (elective freezing of all embryos) received gonadotropin-releasing hormone to trigger egg maturity, followed by a single frozen-thawed mature egg (blastocyst) transfer. The fresh transfer group received human chorionic gonadotropin to trigger egg maturity, followed by a single fresh blastocyst transfer.

No significant differences between groups were observed for pregnancy loss, and none of the women had severe ovarian hyperstimulation syndrome. The risks of complications did not differ between the two groups except for a higher average birth weight after frozen blastocyst transfer and an increased risk of prematurity after fresh blastocyst transfer. Time to pregnancy was longer in the freeze-all group.

Source: https://medicalxpress.com/news/2020-08-chances-pregnancy-higher-frozen-fresh.html
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