Changes in Ganglion cell-inner plexiform layer thickness in
Researchers sought to investigate the ganglion cell–inner plexiform layer (GCIPL) thickness in eyes with nonexudative age-related macular degeneration.

Eyes were classified into four categories—pachydrusen, soft drusen, subretinal drusenoid deposit (SDD), and soft drusen with SDD—and compared the baseline mean macular GCIPL thickness according to the Early Treatment Diabetic Retinopathy Study grid and its change between groups.

--53, 29, 36, and 34 eyes were classified into four categories, respectively. The mean GCIPL thickness values in the 3-mm area were 82.61 ± 9.54 microm for the pachydrusen group, 79.11 ± 10.26 microm for the soft drusen group, 77.72 ± 6.04 microm for the SDD group, and 71.63 ± 8.69 microm for the soft drusen with SDD group.

--The soft drusen with the SDD group showed a greater change in GCIPL thickness in the 3-mm area as compared with the pachydrusen group, soft drusen group, and SDD group.

The GCIPL thickness, in particular, changed depending on the kind of nonexudative age-related macular degeneration. The lower baseline GCIPL and larger change in eyes with soft drusen and SDD could indicate that these eyes had more pronounced neuroretinal degeneration in the central 3-mm area than the other groups.