Characteristics of Pediatric Ulcerative Colitis with Primary
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Ulcerative colitis (UC) is often associated with primary sclerosing cholangitis (PSC). Pediatric UC patients with and without PSC had their clinical characteristics compared.

Researchers retrospectively recruited children with UC, with and without PSC. The clinical data of the patients, including clinical and endoscopic UC severity scores, medications, and laboratory parameters, were analyzed.

Results:
--5 children with PSC-UC (PSC-UC group), and 26 with UC alone (non-PSC UC group) in this retrospective analysis were recruited.

--Among the patients with PSC-UC, 4 were compatible with definite or probable autoimmune sclerosing cholangitis (ASC).

--The UC Endoscopic Index of Severity (5.00 vs. 9.00) and Mayo score (4.00 vs. 8.00) were significantly lower in the PSC-UC group than the non-PSC UC group.

--The prevalence of immunomodulator use was significantly higher in the PSC-UC than the non-PSC UC group, but there was no difference regarding steroids, mesalamine, or biologics.

--At the end of the study, significantly fewer patients were steroid-free in the PSC-UC than the non-PSC UC group (20.0% vs. 84.6%).

In conclusion, pediatric patients with PSC-UC had less serious colitis in terms of the clinical activity index and endoscopic severity index than those with UC alone, but they were more likely to need an immunomodulator and were less likely to be steroid-free in the long run for liver disease control.

Source: https://www.pediatr-neonatol.com/article/S1875-9572(21)00080-2/fulltext?rss=yes
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