Characterization of wound microbes in epidermolysis bullosa,
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Patients with epidermolysis bullosa (EB) require care of wounds that are colonized or infected with bacteria. A subset of EB patients are at risk for squamous cell carcinoma, and bacterial-host interactions have been considered in this risk. The EB Clinical Characterization and Outcomes Database serves as a repository of information from EB patients at multiple centers in the United States and Canada. Access to this resource enabled broad-scale analysis of wound cultures.
A retrospective analysis of 739 wound cultures from 158 patients from 13 centers was done.

-Of 152 patients with a positive culture, Staphylococcus aureus (SA) was recovered from 131 patients (86%), Pseudomonas aeruginosa (PA) from 56 (37%), and Streptococcus pyogenes (GAS) from 34 (22%).
-68% of patients had cultures positive for methicillin sensitive SA, and 47%, methicillin-resistant SA (18 patients had cultures that grew both methicillin-susceptible and methicillin-resistant SA at different points in time).
-Of 15 patients with SA positive cultures with recorded mupirocin susceptibility testing, 11 had mupirocin susceptible SA and 6 patients mupirocin resistant SA (2 patients grew both mupirocin susceptible and mupirocin resistant SA).
-SCC was reported in 23 patients in the entire database, of whom 10 had documented wound cultures positive for SA, PA, and Proteus species in 90%, 50%, and 20% of cases, respectively.

Conclusively, Staphylococcus aureus and Pseudomonas aeruginosa were the most commonly isolated bacteria from wounds. Methicillin resistance and mupirocin resistance were reported in 47% and 40% of patients tested, respectively, highlighting the importance of ongoing antimicrobial strategies to limit antibiotic resistance.