Charles Bonnet syndrome in patients with Stargardt disease:
A Study was conducted to describe the prevalence of the Charles Bonnet syndrome (CBS) and search for potential CBS risk factors in a Dutch Stargardt disease (STGD1) cohort.

83 patients with STGD1 were screened for CBS. They underwent a full eye examination. Participants suspected of CBS were interviewed to further evaluate their visual hallucinations.

Results:
--CBS prevalence was 8.4%. CBS was not associated with age. Patients with CBS had a significant lower social functioning score.

--All 7 patients with CBS were in the category of vision impairment.

--Moreover, first hallucinations manifested after a drop in visual acuity.

--The retinal atrophic area of the worst eye tended to be lower in the CBS group (range 0.11–9.86?mm2) as compared with controls (range 0–180?mm2).

--There was no relation between the position of the scotoma and the location of the visual hallucinations.

In conclusion, the relatively high CBS prevalence in STGD1 shows that CBS may be more common in younger ophthalmic patients than previously thought. There was a female predominance among CBS patients. Age and atrophy of the retinal pigment epithelium were not found as significant risk factors.

Source: https://bjo.bmj.com/content/early/2021/08/03/bjophthalmol-2021-319525?rss=1
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