Clinical Image: Desflurane During Cardiopulmonary Bypass
There is growing evidence of the benefits of halogenated drugs compared to other hypnotics in patients undergoing cardiac surgery [1]. Different trials have shown a protective effect on myocardial level, sevoflurane and desflurane being those who appear to have a greater advantage. At the same time studies show that continuous use of sevoflurane before, during and after cardiopulmonary bypass protects only if it is changed by another anesthetic at some point [2,3].

Desflurane has obvious advantages over other halogenated hydrocarbons, such as partition coefficient lower than allows decrease or increase the concentration in the target organ faster than with any other. However, it has been found that in patients undergoing cardiopulmonary bypass decreased concentration of desflurane in blood is less than that which occurs in a patient breathing normally [4], so that the change in hypnotic during by-pass cardiopulmonary could produce greater than necessary concentrations.....

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https://www.esciencecentral.org/journals/clinical-image-desflurane-during-cardiopulmonary-bypass-2329-9517-1000i103.php?aid=80298
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