Clinical features and follow-up of Pediatric patients hospit
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This report summarizes the clinical features and 1-month follow-up observations for pediatric patients who were hospitalized with coronavirus disease 2019 (COVID-19) in Wuhan Women and Children's Hospital.

The 1-month follow-up data included clinical manifestations and results from serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG and IgM tests, reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2, lung computed tomography (CT) scans, and laboratory tests.

Results:
--127 patients aged 0–15 years were hospitalized for COVID-19 treatment, including 3 severe cases and 124 mild or moderate cases.

--The main therapies included inhalation of aerosolized interferon-alpha and additional antiviral drugs.

--Among the 81 patients who had pneumonia at admission, 35 with right lobe pneumonia had the longest hospital stay; 17 with left lobe pneumonia had the highest creatine kinase and creatine kinase myocardial band (CK-MB, 43±48 U/L) levels; and 29 with bilateral pneumonia had the highest white blood cell counts (8.3±4 × 109/L).

--Among the 46 patients who were successfully followed up 1 month after discharge, two notable findings were right lobe pneumonia in 22% of patients and persistently elevated serum creatine kinase and CK-MB levels.

--The median duration of elevated CK-MB was 45 days. The mean concentrations of serum SARS-CoV-2 IgG and IgM in 41 patients were 8.0±7.5 and 98±40 ng/ml, respectively. At follow-up, 4 patients retested positive for SARS-CoV-2.

Finally, the presence of different lung lobes in COVID-19 patients was linked to differences in the persistence of pneumonia, as well as elevated CKMB levels and body temperature.

Source: https://onlinelibrary.wiley.com/doi/10.1002/ppul.25407?af=R
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