Clinical mimickers of calciphylaxis: a retrospective study
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Calciphylaxis is an ischemic vasculopathy with high morbidity and mortality. Early and accurate diagnosis is critical to management of calciphylaxis, and clinical mimickers may contribute to delayed or misdiagnosis.

This study aimed to assess the misdiagnosis rate, risk factors for misdiagnosis, and clinical mimickers of calciphylaxis. A retrospective medical record review was conducted of patients with calciphylaxis at a large urban tertiary care hospital.

Results:
-- Out of 119 patients eventually diagnosed with calciphylaxis, 73.1% were initially misdiagnosed. In patients not initially misdiagnosed, median time to diagnosis from initial presentation was 4.5 days, compared to 33 days in patients who were initially misdiagnosed.

-- The most common misdiagnoses included cellulitis (31.0%), unspecified skin infection (8.0%), and peripheral vascular disease (6.9%).

-- Patients who were misdiagnosed frequently received at least one course of antibiotics.

-- Patients with end-stage renal disease (ESRD) were less likely to be misdiagnosed than those without ESRD.

Conclusively, an understanding of risk factors for misdiagnosis of calciphylaxis highlights an opportunity for further education of this rare disease.

Source: https://www.jaad.org/article/S0190-9622(21)00581-8/fulltext?rss=yes
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