Clinical relevance of SARS-CoV-2 infection in late pregnancy
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SARS-CoV-2 infection is asymptomatic in three out of five women in late pregnancy, finds a recent study published in the BMC Pregnancy and Childbirth.

To specifically assess the impact of SARS-CoV-2 infection in late pregnancy, investigators prospectively recruited 315 consecutive women delivering in a referral hospital in the early phase of the epidemic. Restriction of the recruitment to this particular historical time period allowed to exclude infections occurring early in pregnancy and to limit the recall bias.

All recruited subjects underwent a nasopharyngeal swab to assess the presence of Sars-Cov-2 using Real-time PCR. In addition, two different types of antibodies for the virus were evaluated in peripheral blood, those against the spike proteins S1 and S2 of the envelope and those against the nucleoprotein of the nucleocapsid. Women were considered to have had SARS-CoV-2 infection in pregnancy if at least one of the three assessments was positive.

- Overall, 28 women had a diagnosis of SARS-CoV-2 infection in pregnancy. Women diagnosed with the infection were more likely to report one or more episodes of symptoms suggestive for Covid-19 compared to unaffected women. The corresponding OR was 4.11.

- Symptoms significantly associated with Covid-19 in pregnancy included fever, cough, dyspnea, and anosmia.

- Only one woman necessitated intensive care. Pregnancy outcomes in women with and without SARS-CoV-2 infection did not also differ.

SARS-CoV-2 infection is asymptomatic in three out of five women in late pregnancy and is rarely severe. In addition, pregnancy outcomes may not be markedly affected.

BMC Pregnancy and Childbirth