Clinical signs associated with earlier diagnosis of children
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The objective of this study is to gain new insights into the relationship between clinical signs and age at diagnosis. Researchers utilize a new, large, online survey of 1743 parents of children diagnosed with ASD, and use multiple statistical approaches. These include regression analysis, factor analysis, and machine learning (regression tree).

Results:
--Researchers find that clinical signs that most strongly predict early diagnosis are not necessarily specific to autism, but rather those that 'initiate the process', eventually leads to an ASD diagnosis.

--Given the high correlations between symptoms, only a few signs are found to be important in predicting early diagnosis.

--For several clinical signs it was found that their presence and intensity are positively correlated with delayed diagnosis (e.g., tantrums and aggression).

Conclusively, in the subset of children without early delays in communication, diagnosis is delayed, and this could be strengthened if more consideration will be paid to clinical signs that are not generally considered as ASD symptoms. Careful consideration should be given to children exhibiting repetitive tantrums or violence, as these actions may interfere with an early ASD diagnosis.

Source: https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-021-02551-0
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