Clinical spectrum of non-syndromic microphthalmos, anophthal
A Study was conducted to describe the clinical features, visual acuity and causes of ocular morbidity in children (0–18 years) with microphthalmos, anophthalmos, and coloboma (MAC) from North India.

A retrospective study conducted in three tertiary eye institutes, part of the Bodhya Eye Consortium with consensus led common pro formas. Children with complete clinical data and without syndromic/systemic involvement were included. The clinical phenotype was divided into isolated ocular coloboma (CB), coloboma with microcornea (CBMC), colobomatous microphthalmos (CBMO), non-colobomatous microphthalmos (MO) and anophthalmos (AO).

Results:
--A total of 532 children with MAC were examined. 515 children were included: 54.4% males and 45.6% females.

--MAC was unilateral in 36% and bilateral in 64%. CB, CBMC, CBMO, MO and AO were seen in 26.4%, 31%, 22%, 8% and 12.5% of eyes, respectively. Nystagmus was found in 40%, strabismus in 23%, cataract in 18.7% and retinal detachment in 15%.

--Best-corrected visual acuity (BCVA) of less than 3/60 was seen in 62.4% eyes. Blindness was seen in 42.8% of bilateral patients.

--Those with microcornea or microphthalmos with coloboma had worse BCVA. There were regional differences in the type of MAC phenotype presenting to the three institutes.

Conclusively, the MAC group of disorders cause significant ocular morbidity. A BCVA is worse predicted because of microcorneal or coloboma microphthalmoses. Aetiology is asked by the variance of the Mac phenotype with the patient's district of origin.

Source: https://bjo.bmj.com/content/105/7/897?rss=1
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