Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascu
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Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease



Siddhartha Jaiswal, M.D., Ph.D., Pradeep Natarajan, M.D., Alexander J. Silver, B.A., C…



June 21, 2017





Abstract

BACKGROUND

Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer. We previously found preliminary evidence for an association between CHIP and atherosclerotic cardiovascular disease, but the nature of this association was unclear.

http://www.nejm.org/doi/full/10.1056/NEJMoa1701719?query=TOC
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