Cobalt chloride 1% petrolatum was more suitable than 0.5%, f
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A recent study showed that cobalt chloride 1% petrolatum (pet.) was more suitable than 0.5%. Cobalt chloride at 1.0% has been patch tested for decades in many European countries and around the world. Analysis was done to know the suitability of patch testing to cobalt 1.0% vs 0.5% and to analyze the co?occurrence of allergy to cobalt, chromium, and nickel.

Results:
--Contact allergy to cobalt was shown in 90 patients (6.6%).
--80 patients tested positive to cobalt.
--37 of the 90 patients with cobalt allergy were missed by cobalt 0.5% and 10 were missed by cobalt 1.0%.
--No case of patch test sensitization was reported.
--Allergy to chromium was seen in 2.6% and allergy to nickel in 13.3%.
--Solitary allergy to cobalt without nickel allergy was shown in 61.1% of cobalt-positive individuals.
--Female patients had larger proportions of positive reactions to cobalt and nickel than males.

Conclusively, the results speak in favor of replacing cobalt chloride 0.5% with cobalt chloride 1.0% pet. in the Swedish baseline series, which will be done 2021.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/cod.13710?af=R
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