Coccidiomycosis infection of the patella mimicking a neoplas
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Coccidioidomycosis is an endemic fungal infection in the southwestern of United States. Most infections are asymptomatic or manifest with mild respiratory complaints. Rare cases may cause extrapulmonary or disseminated disease. This article reports two cases of knee involvement that presented as isolated lytic lesions of the patella mimicking neoplasms.

Case Presentation

The first case, a 27-year-old immunocompetent male had progressive left anterior knee pain for four months. The second case was a 78-year-old male had left anterior knee pain for three months. Both of them had visited general physicians without a conclusive diagnosis. A low attenuation lytic lesion in the patella was demonstrated on their image studies, and the initial radiologist’s interpretation was suggestive of a primary bony neoplasm. The patients were referred for orthopedic oncology consultation.

The first case had a past episode of pulmonary coccidioidomycosis 2 years prior, while the second case had no previous coccoidal infection history. Surgical biopsy was performed in both cases due to diagnostic uncertainty. Final pathologic examination revealed large thick walled spherules filled with endospores establishing the final diagnosis of extrapulmonary coccidioidomycosis.

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