Cocktail Of Drugs Gives First Hope That ‘Biological Age’ Can
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By testing the blood samples from a clinical trial designed to reverse aspects of human aging, scientists found significant reversal in their epigenetic ages.

While they caution their clinical study was small and lacked a control group, they nonetheless say they are optimistic that a person’s biological age can be reversed. Their findings were published yesterday in Aging Cell.

Authors also acknowledged that although “epigenetic age does not measure all features of aging and is not synonymous with aging itself, it is the most accurate measure of biological age and age‐related disease risk available today.” They say the results of their study “bring to light robust evidence that regression of multiple aspects and biomarkers of aging is possible in man.”

“Thymus regeneration and reactivation by growth hormone administration have been established in aging rats and dogs…” the authors wrote. “The present study now establishes highly significant evidence of thymic regeneration in normal aging men accompanied by improvements in a variety of disease risk factors and age‐related immunological parameters...”

“Epigenetic ‘clocks’ can now surpass chronological age in accuracy for estimating biological age,” the study’s authors wrote. Using a protocol intended to regenerate the thymus, the researchers used four such age estimators to assess each patient’s biological age. In the study, nine healthy white men took a combination of three drugs—growth hormone and two diabetes medications—for a year. Not only did participants drop an average of 2.5 years off of their biological ages, but their immune systems showed clinical signs of rejuvenation.

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