Coffee Consumption and Incident Tachyarrhythmias
The notion that caffeine increases the risk of cardiac arrhythmias is common. However, evidence that the consumption of caffeinated products increases the risk of arrhythmias remains poorly substantiated.

This study aimed to assess the association between consumption of common caffeinated products and the risk of arrhythmias. This prospective cohort study analyzed longitudinal data from the UK Biobank. After exclusion criteria were applied, 386?258 individuals were available for analyses.

Any cardiac arrhythmia, including atrial fibrillation or flutter, supraventricular tachycardia, ventricular tachycardia, premature atrial complexes, and premature ventricular complexes.

-- A total of 386?258 individuals (mean [SD] age, 56 [8] years; 52.3% female) were assessed.

-- During a mean (SD) follow-up of 4.5?(3.1) years, 16?979 participants developed an incident arrhythmia.

-- After adjustment for demographic characteristics, comorbid conditions, and lifestyle habits, each additional cup of habitual coffee consumed was associated with a 3% lower risk of incident arrhythmia.

-- In analyses of each arrhythmia alone, statistically significant associations exhibiting a similar magnitude were observed for atrial fibrillation and/or flutter and supraventricular tachycardia.

-- Two distinct interaction analyses, one using a caffeine metabolism–related polygenic score of 7 genetic polymorphisms and another restricted to CYP1A2 rs762551 alone, did not reveal any evidence of effect modification.

-- A mendelian randomization study that used these same genetic variants revealed no significant association between underlying propensities to differing caffeine metabolism and the risk of incident arrhythmia.

Conclusively, in this prospective cohort study, greater amounts of habitual coffee consumption were inversely associated with a lower risk of arrhythmia, with no evidence that genetically mediated caffeine metabolism affected that association. Mendelian randomization failed to provide evidence that caffeine consumption was associated with arrhythmias.