Combined Triple Drug Regimen of Linezolid and Azithromycin i
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A Study was conducted to describe the clinical features, microbiological profile, and outcome of a series of cases of Pythium keratitis treated with topical and oral linezolid and topical azithromycin eye drops.

This was a retrospective interventional case series of microbiologically and/or histopathologically proven cases of Pythium keratitis. All patients received a combination of topical linezolid and/or azithromycin eye drops with oral linezolid. Analysis of demographic data, predisposing risk factors, microbiological results, treatment regimen, visual acuity, surgical intervention, and final outcome was performed.

A subgroup analysis of cases more than 6 mm in size was performed. Success was defined as complete resolution on medical management. Failure was defined as worsening of infection necessitating therapeutic penetrating keratoplasty or evisceration.

Results:
--Of 21 cases, 2 were lost to follow up, 1 was diagnosed on histopathology, and 1 received only topical linezolid.

--Characteristic microbiological features were noted on 10% potassium hydroxide calcofluor white wet mount in 20/21 and Gram stain in 18/21. On triple drug regimen, 14/17 cases resolved.

--Average time to resolution was 87.64 ± 44.44 days. More than 60% infiltrates were large, and 66.66% infiltrates resolved in 109.3 ± 57.06 days.

--Of the 5 failures, 4 needed therapeutic keratoplasty and 1 needed evisceration. All grafts failed.

Conclusively, the dual topical drug regimen with oral linezolid has good cure rates (over 80%) for Pythium keratitis over prolonged duration. It is recommended to persevere with medical therapy even in large infiltrates because more than two thirds resolved.

Source: https://journals.lww.com/corneajrnl/Abstract/2021/07000/Improved_Outcome_of_Pythium_Keratitis_With_a.12.aspx
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