Common Heartburn Drug for COVID-19 Symptoms?
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Treatment options for non-hospitalised patients with COVID- 19 to reduce morbidity, mortality and spread of the disease are an urgent global need. The over-the-counter histamine-2 receptor antagonist famotidine is a putative therapy for COVID-19.

This study quantitively assessed longitudinal changes in patient reported outcome measures in non-hospitalised patients with COVID-19 who self-administered high-dose famotidine orally.

- Data on demographics, COVID-19 diagnosis, famotidine use, drug-related side effects, temperature measurements, oxygen saturations and symptom scores were obtained using questionnaires and telephone interviews.
- Severity scores of five symptoms (cough, shortness of breath, fatigue, headaches and anosmia) and general unwellness on a four-point ordinal scale modelled on performance status scoring was collected.

Results: Ten consecutive patients with COVID-19 who self-administered high-dose oral famotidine were identified. The most frequently used famotidine regimen was 80 mg three times daily for a median of 11 days (range: 5–21 days).

Famotidine was well tolerated. All patients reported marked improvements of disease related symptoms after starting famotidine. The combined symptom score improved significantly within 24 hours of starting famotidine and peripheral oxygen saturation and device recorded activity increased.

Conclusively, The results of this case series suggest that high-dose oral famotidine is well tolerated and associated with improved patient-reported outcomes in non-hospitalised patients with COVID-19.

Source: https://gut.bmj.com/content/early/2020/06/04/gutjnl-2020-321852
Dr. T●●●●z H●●●●●●i and 8 others like this5 shares
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Dr. D●●●●●●●H M●●●●●●R
Dr. D●●●●●●●H M●●●●●●R Dentistry
What is the actual mechanism behind it?
Jun 5, 2020Like
Dr. n●●●i d●●●●r
Dr. n●●●i d●●●●r Internal Medicine
Dear Dr. Palash, Th mechanism of action of Famotidine isn' t certain yet, as this article mentions: "Future work will investigate potential mechanisms of action and clinical relevance of famotidine. Mechanistically, famotidine could have a viral target, for example, one of the viral proteases, or a host target, resulting, for example, in modulation of the immunological response to the virus."
Jun 6, 2020Like1