Comparative Effectiveness of Probiotic strains on the preven
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Atopic dermatitis is the most common chronic skin disease affecting the pediatric population. Probiotics has been proposed to be effective in preventing the development of pediatric atopic dermatitis. A Study was conducted to determine the comparative effectiveness of the different types of probiotic strains in preventing the development of atopic dermatitis among pediatric patients.

The primary outcome of interest was the development of atopic dermatitis. The ranking probabilities and surface under the cumulative ranking curve (SUCRA) values were obtained to determine ranking of the different probiotic strains based on efficacy and safety data.

Results:
--21 original studies represented by 35 records and a total of 5,406 children with atopic dermatitis were included.

--The top 3 probiotic preparations in terms of efficacy in reducing the risk of atopic dermatitis are:
1) Mix8 (Lactobacillus paracasei ST11, Bifidobacterium longum BL999),
2) LP (Lactobacillus paracasei ssp paracasei F19) and
3) Mix3 (Lactobacillus rhamnosus GG, Bifidobacterium animalis ssp lactis Bb 12).

--Mix8 & Mix3 compared to placebo probably reduces the risk of atopic dermatitis based on low quality evidence (RR=0.46 & 0.50).

--In terms of adverse events, LGG may slightly lead to less & Mix4 may slightly lead to more adverse events compared to placebo based on low quality evidence (RR=0.70, RR=1.06).

--Based on subgroup analysis of studies involving infants, Mix3 compared to placebo probably reduces the risk of atopic dermatitis based on low quality evidence (RR=0.46).

--In the subgroup analysis of studies where probiotics were administered to pregnant women and to infants, LRH compared to placebo probably reduces the risk of atopic dermatitis based on moderate quality evidence (RR=0.54).

Certain probiotic preparations demonstrate efficacy in reducing the risk of developing atopic dermatitis when administered to pregnant women, infants, or both.

Source: https://onlinelibrary.wiley.com/doi/10.1111/pai.13514?af=R
Like
Comment
Share