Comparative study of efficacy of nifedipine, nitroglycerin d
Tocolytic agents are used to reduce preterm deliveries. Oral nifedipine was found to be a superior and efficacious tocolytic agent.

The objective was to study and compare the safety efficacy of nifedipine, nitroglycerin dermal patches, and isoxsuprine as tocolytic agents in the suppression of preterm labor.

This was a prospective case-control study conducted for a period of 1 year. Total 90 cases were randomly distributed into three treatment groups viz. A, B, and C nifedipine, nitroglycerin, and isoxsuprine respectively. Subjects in all three groups were evaluated for maternal pulse rate, palpitation uterine contractions, and fetal heart rate in order to assess the efficacy of each drug under investigation.

There was no statistically significant difference in the age of women in three different groups.

- Side effects of nifedipine were less when compared to nitroglycerine dermal patch and isoxsuprine i/v/o of headache, nausea, vomiting, tachycardia, palpitation, hypotension.

- Side effects were significantly different between the treatment groups. There was no statistically significant difference with respect to APGAR score at 1 minute and 5 minutes.

In conclusion, oral nifedipine was found to be superior and efficacious as a tocolytic agent as compared to transdermal nitroglycerin and intravenous isoxsuprine.

International Journal of Reproduction, Contraception, Obstetrics & Gynecology
Source: https://dx.doi.org/10.18203/2320-1770.ijrcog20212672
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