Conception rates in women desiring pregnancy after levonorge
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Evaluate reproductive function in nulligravid and gravid women after levonorgestrel 52 mg intrauterine system (IUS) discontinuation based on time to pregnancy.

Researchers evaluated women participating in the ACCESS intrauterine system multicenter, Phase 3, open-label clinical trial of the Liletta(®) levonorgestrel 52 mg intrauterine system who discontinued the intrauterine system within 60 months of use and desired pregnancy. Study staff contacted participants every three months after intrauterine system discontinuation for up to 12 months to determine whether pregnancy occurred. They evaluated 12-month conception rates in participants 16–35 years at intrauterine system placement, comparing dichotomous outcomes using Fisher’s exact test.

Among 165 women who attempted to conceive, 142 did so within 12 months with a median time to conception of 92 days. The 12-month conception rates did not differ between nulligravid and gravid women and nulliparous and parous women. In multivariable analysis, only obesity was associated with the ability to conceive.

After levonorgestrel 52 mg intrauterine system discontinuation, women have a rapid return of fertility in the year post-removal. Fertility rates after intrauterine system removal do not vary based on gravidity, parity, age at discontinuation, or duration of intrauterine system use. This contemporary intrauterine system study included a large population of nulligravid and nulliparous women. IUS use over many years does not affect spontaneous fertility after intrauterine system discontinuation, regardless of gravidity or parity. Providers and patients should have no concern about the impact of intrauterine system use on future fertility.

Source:https://www.sciencedirect.com/science/article/abs/pii/S0010782420303553
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