Congenital malaria: Is it really rare? - IJCH
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Congenital malaria (CM) is believed to be rare due to belief that physical barrier of placenta to infected red cells, passive transfer of maternal antimalarial antibodies, and poor plasmodial replication in low free oxygen tension in fetal hemoglobin protect a neonate from acquiring malarial infection. A 7-day-old term male infant weighing 2.4 kg was admitted with fever, pallor, icterus, and splenomegaly for 3 days. The primi mother was treated for pyrexia in the last trimester. Investigation revealed anemia, hyperbilirubinemia, and thrombocytopenia and demonstrated Plasmodium vivax in peripheral blood smear and card test. C-reactive protein was raised and blood culture was sterile.The baby was responded well to intravenous (IV) artesunate. Recent studies suggest that congenital malaria (CM) is not as rare as previously thought. Cord blood shows greater parasitemia as compared to neonatal blood. Besides light microscopy, plasmodium antigen detection and polymerase chain reaction of blood may help in diagnosis. CM can be confused with toxoplasmosis, rubella, cytomegalovirus, herpes simplex syndrome, and neonatal sepsis....

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