Conjunctival Vessels in Diabetes Using Functional Slit Lamp
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This study used functional slit-lamp biomicroscopy (FSLB) to quantify conjunctival microvessel parameters in individuals with and without diabetes and examined whether these metrics could be used as surrogate markers of diabetes-related complications.

A cross-sectional study of 98 controls (C), 13 individuals with diabetes without complications (D–C), and 21 with diabetes and related complications (D+C), which included retinopathy, nephropathy, neuropathy, and cardiovascular-, peripheral vascular-, and cerebrovascular diseases, was performed. Bulbar conjunctival metrics (venule diameter, length, axial velocity [Va], cross-sectional velocity [Vs], flow [Q], and branching complexity) were measured using functional slit-lamp biomicroscopy (digital camera mounted on traditional slit lamp).

The mean age was 60 ± 11 years, and demographics were similar across the groups. axial velocity and cross-sectional velocity significantly differed between groups. axial velocity was 0.51 ± 0.17 mm/s, 0.62 ± 0.17 mm/s, and 0.45 ± 0.17 mm/s in the controls and individuals with diabetes without complications, and diabetes and related complications groups, respectively. Similarly, Vs was 0.35 ± 01.12, 0.43 ± 0.13, and 0.32 ± 0.13 mm/s in the controls, individuals with diabetes without complications, and diabetes and related complications groups, respectively. Black individuals had increased Va, cross-sectional velocity, and flow compared with White individuals, but differences in velocities persisted after accounting for the race. Among patients with diabetes, axial velocity and cross-sectional velocity correlated with a number of organ systems affected. Axial velocity, cross-sectional velocity, and flow significantly discriminated between diabetic patients with and without complications.

Bulbar conjunctival blood flow metrics measured by functional slit-lamp biomicroscopy differed between controls, diabetic patients without complications, and diabetic patients with complications. Functional slit-lamp biomicroscopy is a quick, easily accessible, and noninvasive alternative that might estimate the burden of vascular complications in diabetes.

Source:https://journals.lww.com/corneajrnl/Abstract/9000/Conjunctival_Vessels_in_Diabetes_Using_Functional.95878.aspx
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