Continuous infusion of Hypertonic saline vs Standard care on
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This JAMA study suggests that among patients with moderate to severe traumatic brain injury, treatment with continuous infusion of 20% hypertonic saline compared with standard care did not result in a significantly better neurological status at 6 months.

The objective was to determine whether the continuous infusion of hypertonic saline solution improves neurological outcomes at 6 months in patients with traumatic brain injury.

A multicenter randomized clinical trial was conducted in 9 intensive care units in France, including 370 patients with moderate to severe traumatic brain injury. Adult patients with moderate to severe traumatic brain injury were randomly assigned to receive a continuous infusion of 20% hypertonic saline solution plus standard care (n=185) or standard care alone (controls; n=185).

--The adjusted common OR for the GOS-E score at 6 months was 1.02. Of the 12 secondary outcomes, 10 were not significantly different.

--Intracranial hypertension developed in 62 patients in the intervention group and 66 patients in the control group.

--There was no significant difference in 6-month mortality.

In particular, among patients with moderate to severe traumatic brain injury, treatment with continuous infusion of 20% hypertonic saline compared with standard care did not result in a significantly better neurological status at 6 months.

Source: https://jamanetwork.com/journals/jama/article-abstract/2780326
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