Coronavirus linked to stroke in otherwise healthy young peop
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
Surgeons at Thomas Jefferson University analyzed patients presenting with stroke from March 20th until April 10th at their institutions. The strokes they observed were unlike what they usually see.

The researchers examined 14 patients who had come into their Neurointerventional room for stroke. Eight patients were male, six were female, 50%, did not know they had the coronavirus, while the remainder were already being treated for other symptoms of the disease when they developed stroke.

Some major observations:

-- Patients with signs of stroke were delaying coming to the hospital for fear of getting the coronavirus. There's a small window of time in which strokes are treatable, so delays can be life threatening.
-- The mortality rate in these covid-19 stroke patients is 42.8%. The typical mortality from stroke is around 5 to 10%.
-- 42% of the stroke coronavirus positive patients studied were under the age of 50. Most strokes, over 75% of all strokes in the US, occur in people over the age of 65.
-- The incidence of coronavirus in the stroke population was 31.5%, according to this sample of patients.
-- Patients observed had stroke in large vessels, in both hemispheres of the brain, and in both arteries and veins of the brain -- all of these observations are unusual in stroke patients.

Why is the coronavirus, which was assumed to be a disease of the lungs, causing blood clots that lead to a higher incidence of stroke?

- Researchers have shown that the coronavirus enters human cells via a very specific access point -- a protein on human cells called ACE2. But the coronavirus latches onto this protein and uses it to as a gateway into the cell, where the virus can replicate. Not all cells have the same amount of ACE2. This protein is very abundant on cells that line blood vessels, the heart, kidney, and of course, the lungs. Researchers speculate that the virus may be interfering with this receptor's normal function, which controls blood flow in the brain, in addition to using it as an entry point to the cell.

- Another possibility is that the inflammation of the blood vessels causing vasculitis with injury to the cells lining the lumen of the vessel, called endothelium and causing micro thrombosis in small vessels.

"These observations, though preliminary, can serve as a warning for medical personnel on the front lines, and for all of those at home," says researchers.

Source: https://academic.oup.com/neurosurgery/advance-article/doi/10.1093/neuros/nyaa254/5850415
Dr. S●●●●●m S●●●●y P●●●●●l and 5 others like this8 shares
Like
Comment
Share
Dr. S●●●●●m S●●●●y P●●●●●l
Dr. S●●●●●m S●●●●y P●●●●●l General Medicine
Interesting read. The need to find a safe way to treat coronavirus along with comorbid conditions and formulating guidelines has now become the need of the hour.
Jun 8, 2020Like1