Correlation of Insulin Resistance in Pregnancy with Obstetri
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Pregnancy is characterized by a series of metabolic changes that promote insulin resistance. This could be due to an increase in the plasma levels of one or more pregnancy-related hormones. The increased insulin resistance in pregnancy is associated with the development of diabetes which has implications for future gestations also.

The aim was to determine the status of insulin resistance in pregnant women and correlate the presence of insulin resistance with obstetric outcomes.

Total 150 pregnant women were enrolled from OPD, out of which 136 women were followed up till delivery. Insulin resistance was calculated by the HOMA IR index, twice in the whole antenatal period (first in early pregnancy and second in late pregnancy). All women were also tested for GDM by DIPSI test (plasma glucose value after 2 h of 75 gm glucose load irrespective of last meal) as per protocol.

In the study, they found 71 women out of 136 were GDM. A total of 30 women was GGI (Gestational Glucose Intolerance), and a total of 38 women were found to have insulin resistance using HOMA IR???2 as cut off.

--A significant correlation was found between BMI and insulin resistance and between GDM and insulin resistance.

--The relative risk of development of complications like Preeclampsia, neonatal hypoglycemia, and respiratory distress syndrome was higher in women having insulin resistance and GDM.

In particular, obstetric complications like preeclampsia, neonatal hypoglycemia, and respiratory distress syndrome are more likely to occur in women with insulin resistance.

Source: https://doi.org/10.1007/s13224-021-01426-9
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