Correlation of macular sensitivity measures and visual acuit
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Visual acuity is commonly used as a functional outcome measure in patients with age-related macular degeneration (AMD), despite having a weak correlation with self-perceived visual quality of life. Microperimetry is a useful method of detecting loss of macular function. A Study was conducted to investigate the relationship between these two objective visual outcome measures and subjective vision-related quality of life, finding out which objective measure is more patient-relevant.

51 consecutive patients with AMD were recruited to the study. Participants were required to complete the Visual Function Questionnaire 39, the Early Treatment Diabetic Retinopathy Study visual acuity examination and a microperimetry assessment using the Micro Perimeter 3.

43 patients with AMD were included in the study: 28 patients with late AMD (exudative AMD) and 15 patients with early (non-exudative) AMD. The right eye was included as standard, as was the eye with the best-corrected visual acuity.

Results:
--There was a higher correlation between vision-related quality of life and macular sensitivity (r=0.458) than between vision-related quality of life and visual acuity (r=0.446) in patients with late AMD.


--There was a positive correlation between vision-related quality of life and macular sensitivity in patients with early AMD (r=0.542) while the correlation between vision-related quality of life and visual acuity in these patients was not statistically significant.

--Composite score (r=0.469) correlated highest with the nasal outer macular sub-region and near-distance activities score (r=0.652) correlated highest with the nasal inner macular sub-region in patients with late AMD.

--Correlations between composite score and macular sub-regions in patients with early AMD were not significant, but near-distance activities score correlated with the nasal outer macular sub-region in these patients (r=0.469).

Finally, in both early and late AMD, macular sensitivity as calculated by microperimetry correlates with vision-related quality of life, indicating that it is a patient-relevant outcome test. Furthermore, the nasal sub-regions of the macula appear to be preferred retinal loci in patients with AMD.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-01901-x
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