Correlation of menopausal symptoms with Serum Estradiol
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Menopause is a hypoestrogenic state. Menopausal symptoms like hot flushes, depression, joint pains, and urinary symptoms all correlate with falling estrogen levels.

400 postmenopausal women who underwent natural menopause were included in the study. Surgical menopause, premature menopause, and those on hormone replacement were excluded.

Serum estradiol was measured and assessment of the severity of menopausal symptoms was done using MRS questionnaire. MRS scores of 0–4, 5–8, 9–15, and more than 16 were taken as none/minimal, mild, moderate, and severe postmenopausal symptoms, respectively. The correlation between serum estradiol and symptoms was analyzed statistically.

- The mean age of menopause in our study population was found to be 47.2±3.96 years.

- Somatic symptoms were found maximum out of all 3 subscales in the study population.

- The psychological subscale which included depression and mood changes was found to have the strongest correlation with serum estradiol level compared to the other two subscales (somatic and genito-urinary).

In particular, there is an inverse correlation of serum estradiol value with menopausal symptoms, with psychological symptoms (depression, anxiety, mood changes) showing the highest correlation with low estrogen levels.

The Journal of Obstetrics and Gynecology of India
Source: https://doi.org/10.1007/s13224-021-01518-6
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