Corticosteroid-Binding Globulin Deficiency Independently Pre
Hydrocortisone administration in septic shock remains controversial. Corticosteroid-binding globulin (CBG) transports cortisol to inflammatory sites and is depleted in septic shock.
Septic shock patients with CBG <200 nmol/L had higher norepinephrine requirements and 3.2-fold higher ICU mortality. CBG concentration was the only directly reversible independent mortality risk factor.

Source: https://academic.oup.com/jcem/article/107/6/1636/6527941?login=false
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