Covariation of changing patent Ductus Arteriosus management
Researchers aimed to test the hypothesis that NICU-specific preterm infant outcomes co-vary with changes in local patent ductus arteriosus (PDA) management.

This retrospective multicenter study examined NICU-specific aggregated data for infants born 400–1499 g (VLBW). Proportion of infants receiving cyclooxygenase inhibitor (COXI) and/or PDA ligation were calculated and determined NICU-specific changes in these therapies between consecutive years. Researchers examined relationships between NICU-specific changes in COXI/ligation and concurrent changes in local adjusted in-hospital outcomes.

Results:
--In 5678 observations of change at 259 NICUs summarizing 78,105 infants, between-year decreases in NICU-specific proportion treated with COXI/ligation were associated with concurrent increases in local mortality and decreases in BPD among infants 400–749 g, and with decreased pulmonary hemorrhage in larger infants.

Conclusively, NICU-specific adjusted mortality, BPD, and pulmonary hemorrhage rates co-vary with changes in local COXI/ligation rates in some VLBW infant subgroups.

Source: https://www.nature.com/articles/s41372-021-01170-y
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