Covaxin Found To Be Effective Against Brazilian Variant Of V
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The indigenously developed Covaxin is capable of fighting the Brazilian variant too, according to the latest study on Covid-19 vaccine. Earlier, Covaxin was found to fight the UK variant, B.1.1.7, and the so-called double mutant of Maharashtra, B.1.617.

Researchers studied the neutralisation efficacy of the Brazilian variant, B.1.1.28.2, with the convalescent sera of individuals with natural infection and those, who received two doses of Covaxin. They found that individuals after receiving two doses of Covaxin had their immunity boosted against the Brazilian variant.

The Brazilian variant, which was earlier assigned the technical name, B.1.1.248, is now reclassified as B.1.128.2. Also, the variant was thought to belong to two lineages – P1 and P2. But now, scientists recognise it as one variant with a single lineage. However, in India the Brazilian variant is not as widely present as the double mutant, B.1.617.

“The two-dose vaccine regimen significantly boosted the IgG titre and neutralizing efficacy against both B.1.1.28.2 (Brazilian variant) and D614G variants compared to that seen with natural infection. The study demonstrated 1.92 and 1.09 fold reductions in the neutralizing titre against B.1.1.28.2 variant in comparison with prototype D614G variant with sera of vaccine recipients and natural infection respectively,” the research said.

They said the two-dose Covaxin regimen significantly boosted the antibodies and neutralising efficacy against both the variants compared to that seen with natural infection. A vaccine that uses an inactivation platform has been reported to be 50.7% efficacious from Brazil, where the B.1.1.28.2 variant is more prevalent.

Source:
https://health.economictimes.indiatimes.com/news/industry/icmr-covaxin-found-to-be-effective-against-brazilian-variant-of-virus-too/82363145
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